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Cholinesterase Inhibition Activity of Marsilea Quadrifolia Linn. an Edible Leafy Vegetable from West Bengal, India

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Title Cholinesterase Inhibition Activity of Marsilea Quadrifolia Linn. an Edible Leafy Vegetable from West Bengal, India
 
Creator Bhadra, Santanu
Mukherjee, Pulok K
Bandyopadhyay, Arun
 
Subject Cell Biology & Physiology
 
Description Maesilea quadrifolia Linn. (Marsileaceae) is a leafy vegetable well known in India.
The current study aims to explore the phytochemical profile of M. quadrifolia and
investigate its anti-cholinesterase potential. The methanol extract of the plant was
subjected to qualitative and quantitative phytochemical screening (total alkaloidal
content, saponin content and phenol content) and its anti-cholinesterase
potential was tested by TLC bioautography and other screening methods using
acytylcholinesterase (AChE) and butyrylcholinesterase (BChE). The study
revealed that the extract contains various classes of phytoconstituents including
steroids, saponins, alkaloids and other polyphenols. Total alkaloid, phenolic and
saponin contents were found to be 19.3 mgg�1 and 158.5�1.02mg g�1 as gallic
acid equivalents and 2.63 mgg�1 of the extract, respectively. The TLC
bioautography method exhibited the inhibition of both enzymes. In a microtiter
plate assay, the IC50 values of the extract for AChE and BChE were found to be
51.89�0.24 mgmL�1 and 109.43�2.82 mgmL�1, respectively. These findings
suggest that M. quadrifolia is a potential lead as an AChE and BChE inhibitor,
which may be useful in the management of Alzheimer’s disease.
 
Publisher Taylor & Francis
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1672/1/NATURAL_PRODUCT_RESEARCH___26_(_16)_1519%2D1522;2012[149].pdf
Bhadra, Santanu and Mukherjee, Pulok K and Bandyopadhyay, Arun (2012) Cholinesterase Inhibition Activity of Marsilea Quadrifolia Linn. an Edible Leafy Vegetable from West Bengal, India. Natural Product Research, 26 (16). pp. 1519-1522. ISSN 1478-6419
 
Relation http://dx.doi.org/10.1080/14786419.2011.565006
http://www.eprints.iicb.res.in/1672/