Record Details

Hepatoprotective Activity of the Edible snail (Bellamia bengalensis) Flesh Extract in Carbon Tetrachloride Induced Hepatotoxicity in Rats

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Hepatoprotective Activity of the Edible snail (Bellamia bengalensis) Flesh Extract in
Carbon Tetrachloride Induced Hepatotoxicity in Rats
 
Creator Gomes, Antony
Alam, Mohammed Aftab
Datta, Poulami
Bhattacharya, Shamik
Gomes, Aparna
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Ethnopharmacological relevance: In the folk-traditional medicine, snails were used to purify blood, boost
immune system, prevent conjunctivitis and to treat liver problems.
Objectives: To evaluate the hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract
in male Wistar rats treated with carbon tetrachloride as an hepatotoxicant.
Materials and methods: Live adult Bellamia bengalensis was collected commercially from the Kolkata market.
Aqueous flesh extract (BBE) was prepared in 0.9% saline and expressed in terms of wet weight basis.
The aqueous flesh extract was administered orally (1, 2 g kg−1 day−1) to male rats for 12 days. Liv52 was
used as positive control. 24 h after administration of extract, the rats were given a single oral dose of
CCl4 (1.25 ml kg−1), except vehicle control rats. After 24 h of CCl4 administration, all the animals were
sacrificed to collect the blood and liver tissue.
Results: BBE (1 and 2 g kg−1 day−1, p.o.
×
12 days) significantly prevented CCl4 induced elevation of SGOT,
SGPT, �GT, ACP, ALP, bilirubin, LDH and CCl4 induced decrease in total protein, triglyceride level in male
Wistar rats. BBE treated rat liver anti-oxidant parameters (LPO, SOD, GSH, CAT, GPx) were significantly
antagonized for the pro-oxidant effect of CCl4. Histopathological studies also supported the protective
effect of BBE.
Conclusion: This study validated the folk and traditional use of snail in liver disorder through CCl4-induced
rat experimental model
 
Publisher Elsevier
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1678/1/ethno_paper%2B2011.pdf
Gomes, Antony and Alam, Mohammed Aftab and Datta, Poulami and Bhattacharya, Shamik and Gomes, Aparna (2011) Hepatoprotective Activity of the Edible snail (Bellamia bengalensis) Flesh Extract in Carbon Tetrachloride Induced Hepatotoxicity in Rats. Journal of Ethnopharmacology, 138. pp. 228-232.
 
Relation http://dx.doi.org/10.1016/j.jep.2011.09.009
http://www.eprints.iicb.res.in/1678/