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Design, Synthesis and Biological Evaluation of Some Novel Antioxidant–Antiapoptotic Molecules to Protect Organ Damage Due to Oxidative Stress

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Title Design, Synthesis and Biological Evaluation of Some Novel Antioxidant–Antiapoptotic Molecules to Protect Organ Damage Due to Oxidative Stress
 
Creator Pal, Chinmay
 
Subject Infectious Diseases and Immunology
 
Description Reactive oxidants-induced activation of apoptosis or cell death plays a pivotal role for the pathogenesis of various diseases. Mitochondrial generation of reactive oxidants actually causes damage to cellular macromolecules including nucleic acids, phospholipids and proteins and ultimately leads to mitochondrial dysfunction, which accounts for the
pathogenesis of wide spectrum of human diseases such as cancer, diabetes, neuropathies, myopathies, cardiovascular disease, gastric ulcer and hepatitis. Therefore, an antioxidant, which will prevent oxidative stress developed due to mitochondrial dysfunction, will be beneficial for the treatment of above diseases. The aim of the current study will be to design, synthesis and evaluation of antioxidant–antiapoptotic molecules based on several antioxidant scaffolds. Mitochondrial oxidative stress plays the central role in nonsteroidal antiinflammatory drugs-induced gastropathy. Therefore, to evaluate the biological activity of newly synthesized molecules, animal model like nonsteroidal antiinflammatory drugsinduced gastropathy in rat will be utilized. The lead molecule identified will be structurally and functionally validated with a view to explore chemotherapeutic potential for protecting
gastric mucosal damage caused by reactive oxidants. Furthermore, free heme offers toxic effects to tissues and organs through oxidative stress by generating reactive oxidants and redox-active iron. Pro-oxidant effect of heme, affects the function of kidneys, neurons, cardiac cells, hepatocytes, and peripheral leukocytes. Hemin in the aqueous phase frequently aggregates in the membrane and promotes oxidation, which leads to the enhancement of
permeability and membrane disorder. Therefore, identification of effective small molecules that prevents heme-mediated oxidative stress and associated disorders is highly required.
 
Date 2012
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1687/1/CHINMAY_PAL_THESIS.pdf
Pal, Chinmay (2012) Design, Synthesis and Biological Evaluation of Some Novel Antioxidant–Antiapoptotic Molecules to Protect Organ Damage Due to Oxidative Stress. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1687/