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Development of Elegant Methods for the Synthesis of Novel Heterocycles

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Title Development of Elegant Methods for the
Synthesis of Novel Heterocycles
 
Creator Sasmal, Anup Kumar
 
Subject Chemistry
 
Description Heterocyclic compounds have attracted much pharmacological and synthetic interest as they have been found in many biologically important scaffolds. Therefore, development
of efficient and elegant methodologies for the synthesis of novel fused heterocycles of biological significance is a challenging task in organic chemistry. The research work
embodied in this thesis describes efficient and elegant protocols for the synthesis of triazole fused benzoxazines, triazole fused benzodiazepines/benzodiazocines and
pyrazole fused benzodiazepines applying palladium-copper catalyzed reactions and 1,3- dipolar cycloaddition. The work has been presented in three Chapters.Describes the efficient synthesis of 3-aryl substituted [1,2,3]triazolo[5,1-
c][1,4]benzoxazines using palladium and copper catalysts in one-pot through Sonogashira coupling followed by azide-alkyne cycloaddition.Describes a facile and expedient general synthesis of novel tricyclic scaffolds 3-aryl substituted [1,2,3]triazolo[1,5-a][1,4]benzodiazepin-6-ones and[1,2,3]triazolo[1,5-a][1,5]benzodiazocin-7-ones through Sonogashira coupling followed by in situ diazotization, azidation and azide-alkyne cycloaddition reactions.
 
Date 2011
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1689/1/ANUP_K_SASMAL%2DPhD%2DTHESIS%2D2011..pdf
Sasmal, Anup Kumar (2011) Development of Elegant Methods for the Synthesis of Novel Heterocycles. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1689/