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Studies on the Structural and Energetic Aspects of the Interaction of Phenazinium Dyes with Deoxyribonucleic Acids

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Title Studies on the Structural and Energetic Aspects of the Interaction of Phenazinium Dyes with Deoxyribonucleic Acids
 
Creator Saha, Ishita
 
Subject Chemistry
 
Description Nucleic acids are the central molecules in transmission, expression and conservation of genetic information.
Nucleic acids were first discovered by Friedrich Miescher in 1871. This Swiss physician and biologist isolated
various phosphate-rich chemicals, which he called nuclein (now nucleic acids), from the nucleic acids of
white blood cells in 1869.
After Miescher’s initial description in 1871, other scientists also started investigations into
nuclein. However, for long after Miescher’s death, nuclein still received comparatively little attention. The
role of DNA as the carrier of genetic information has been amply demonstrated beginning with the classic
experiments of Avery1and Hershey and Chase2. Identifying DNA as the code of life was a remarkable discovery.
However, uncovering the structure of DNA would prove to be the key to understand the role it plays in
the formation of life. This structure has novel features which are of considerable biological interest. The classic
example of how biological functions follow from biomolecular structures comes from the elucidation of the
structure of DNA as a double helix by Watson and Crick3 using the X-ray fiber diffraction patterns
generated by Franklin, Wilkins, and their associates.4,5 “We wish to suggest a structure for the salt of
deoxyribonucleic acid (DNA)” –this was the opening remark in the paper published in the Nature magazine
by Watson and Crick announcing discovery of the structure of DNA in the year 1953. This discovery is often
said to mark the birth of modern molecular biology.
 
Date 2012
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1692/1/Ishita_Saha_Thesis.pdf
Saha, Ishita (2012) Studies on the Structural and Energetic Aspects of the Interaction of Phenazinium Dyes with Deoxyribonucleic Acids. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1692/