Record Details

Arsenic Exposure Through Drinking Water Increases the rRsk of Liver and Cardiovascular Diseases in the Population of West Bengal, India

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Arsenic Exposure Through Drinking Water Increases the rRsk of Liver and Cardiovascular Diseases in the Population of West Bengal, India
 
Creator Das, Nandana
Paul, Somnath
Chatterjee, Debmita
Banerjee, Nilanjana
Majumder, Niladri S
Sarma, Nilendu
Sau, Tanmoy J
Basu, Santanu
Banerjee, Saptarshi
Majumder, Papiya
Bandyopadhyay, Apurba K
States, J Christopher
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description Background: Arsenic is a natural drinking water contaminant affecting 26 million people in West Bengal, India.
Chronic arsenic exposure causes cancer, cardiovascular disease, liver disease, neuropathies and ocular diseases. The
aims of the present study were to assess bioindicators of hepatocellular injury as indicated by the levels of liver
enzymes, to determine the auto immune status, as indicated by the amounts of anti-nuclear antibodies (ANA) and
anti-dsDNA antibodies in their serum, and to predict cardiovascular risk in the arsenic exposed population.
Methods: Effect of chronic arsenic exposure on liver was determined by liver function tests. Autoimmune status
was measured by measuring ANA and anti-dsDNA in serum. Inflammatory cytokines associated with increased
cardiovascular disease risk, IL6, IL8 and MCP-1 were determined.
Results: Our results indicated that serum levels of bilirubin, alanine transaminase, aspartate transaminase, alkaline
phosphatase and ANA were increased in the arsenic exposed population. Serum levels of IL6 and IL8 also increased
in the arsenic exposed group.
Conclusions: Chronic arsenic exposure causes liver injury, increases the serum levels of autoimmune markers and
imparts increased cardiovascular risk.
Keywords: Arsenic, Antinuclear antibody, Liver function tests, Cytokines
 
Publisher BioMed Central
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1716/1/BMC_PUBLIC_HEALTH___12(_639);2012[51].pdf
Das, Nandana and Paul, Somnath and Chatterjee, Debmita and Banerjee, Nilanjana and Majumder, Niladri S and Sarma, Nilendu and Sau, Tanmoy J and Basu, Santanu and Banerjee, Saptarshi and Majumder, Papiya and Bandyopadhyay, Apurba K and States, J Christopher and Giri, Ashok K (2012) Arsenic Exposure Through Drinking Water Increases the rRsk of Liver and Cardiovascular Diseases in the Population of West Bengal, India. BMC Public Health, 12 (639).
 
Relation http://dx.doi.org/10.1186/1471-2458-12-639
http://www.eprints.iicb.res.in/1716/