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Advances in Microbial Biotechnology of Bile Acides

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Title Advances in Microbial Biotechnology of Bile Acides
 
Creator Mahato, Shashi B
Mukherjee, Emele
Banerjee, Sukdeb
 
Subject Chemistry
 
Description The recent advances in mlcroblal biotechnology of production of
bile acid metabolites helped to identify a number of neutral and acidic
steroidal compounds useful as drugs and drug intermediates on a scale
which would not have been possible by classical chemical transformations.
Microbial transformations vlz., hydroxylation, dehydroxylation,
reduction of the carbonyl moieties, eplmerlzation, slde-chaln metabollsm,
introduction of carbon-carbon double bonds into the steroid nucleus,
deconjugation of bile acid conlugates carried out by various microorganisms
for production of useful metaboiltes wlth special reference to newer
techniques including ceil immobl]/zatlon and transposon mutagenesis for
selective transformations are reviewed. The different pathways of
microbial degradation of bile acids leading to the formation of various
products are discussed. A compilation of the metaboiltes formed by
various microorganisms from the bile acids or their conjugates and
reported during the period 1979-1992 is also provided
 
Publisher Elsevier
 
Date 1994
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1767/1/BIOTECHNOLOGY_ADVANCES__12(_2)_357%2D391;1994[69].pdf
Mahato, Shashi B and Mukherjee, Emele and Banerjee, Sukdeb (1994) Advances in Microbial Biotechnology of Bile Acides. Biotechnology Advances, 12 (2). pp. 357-391.
 
Relation http://dx.doi.org/10.1016/0734-9750(94)90017-5
http://www.eprints.iicb.res.in/1767/