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Decrease in b-Adrenergic Receptors of Cerebral Astrocytes in Hypothyroid Rat Brain

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Title Decrease in b-Adrenergic Receptors of Cerebral Astrocytes in Hypothyroid Rat Brain
 
Creator Das, Sumantra
Paul, Surojit
 
Subject Cell Biology & Physiology
 
Description Studies on the binding of 3H-dihydroalprenolol (3H-DHA) to astrocytes
from cerebra of normal and hypothyroid rats show that hypothyroidism
results in a decline in the ~-adrenergic receptors.
Ontogenic studies indicated that in normal, euthyroid rats, the
maximum binding capacity (Bmax) for 3H-DHA progressively increased
with age while the affinity (Kd) remained unaltered. In astrocytes
prepared from hypothyroid rats, total number of binding
sites for 3H-DHA also increased with age, however, at a given age,
the number was significantly lower than that for corresponding
euthyroid animals while the affinity for 3H-DHA remained unaffected.
Correspondingly, primary cultures of astrocytes from normal
and hypothyroid brain when maintained in TH-deficient serum,
display a similar reduction of 3H-DHA binding. In the case of
astrocytes from hypothyroid brain cultured in TH-dfficient serum,
the decline can be largely restored by supplementing with normal
serum. Results suggest that thyroid hormones (TH) directly or
indirectly regulates the level of ~-adrenergic receptors in
astrocytes from developing rat brain.
 
Publisher Elsevier
 
Date 1994
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1776/1/LIFE_SCIENCES___54(_9)_621%2D629;1994[76].pdf
Das, Sumantra and Paul, Surojit (1994) Decrease in b-Adrenergic Receptors of Cerebral Astrocytes in Hypothyroid Rat Brain. Life Sciences, 54 (9). pp. 621-629.
 
Relation http://dx.doi.org/10.1016/0024-3205(94)00868-X
http://www.eprints.iicb.res.in/1776/