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Effect of Bioamines on Uptake of Promastigotes of Leishmania Donovani by Hamster Peritoneal Macrophages

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Title Effect of Bioamines on Uptake of Promastigotes of Leishmania Donovani by Hamster Peritoneal Macrophages
 
Creator Mitra, Smita
Ghosh, Lagnajita
Chakrabarty, Pampa
Biswas, Madhumita
Bhattacharyya, F. Kathlene
Ghosh, D K
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Epinephrine and norepinephrine inhibit attachment of Leishmania donovani
promastigotes to cultured hamster peritoneal macrophages. The inhibition was significant at catecholamine concentrations of and 1 0 - 5 M and occurred when they were added to the cell mixtures, or after pre-treatment of either macrophages or parasites. Inhibition of attachment after pre-treatment was less marked than when the catecholamines were added to parasite-cell mixtures. Similar results were obtained with dibutyryl cyclic AMP, cholera toxin, theophylline, and cadaverine which raise intracellular cyclic AMP (CAMP). Pretreatment of parasites or macrophages with the bioamines elevated the intracellular cAMP concentration. It is suggested that the inhibitory effect on the host-parasite interaction is mediated through CAMP
 
Publisher Society for General Microbiology
 
Date 1992
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1795/1/JOURNAL_OF_MEDICAL_MICROBIOLOGY___36_(_4)_283%2D287;1992[43].pdf
Mitra, Smita and Ghosh, Lagnajita and Chakrabarty, Pampa and Biswas, Madhumita and Bhattacharyya, F. Kathlene and Ghosh, D K (1992) Effect of Bioamines on Uptake of Promastigotes of Leishmania Donovani by Hamster Peritoneal Macrophages. Journal of Medical Microbiology, 36 (4). pp. 283-287. ISSN 0022-2615
 
Relation http://dx.doi.org/10.1099/00222615-36-4-283
http://www.eprints.iicb.res.in/1795/