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Synthesis and in Vitro Study of Antibacterial, Antifungal Activities of some Novel Bisquinolines

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Title Synthesis and in Vitro Study of Antibacterial, Antifungal Activities
of some Novel Bisquinolines
 
Creator Sahu, Krishnendu B
Ghosh, Soma
Banerjee , Maitreyee
Maity, Arindam
Mondal, Shyamal
Paira , Rupankar
Saha , Pritam
Naskar, Subhendu
Hazra , Abhijit
Banerjee, Sukdeb
Samanta, Amalesh
Mondal, Nirup B
 
Subject Chemistry
 
Description Efficient syntheses of a series of novel bisquinolines
have been accomplished from8-hydroxy quinolines under
phase transfer catalyzed conditions using tetrabutylamoniumbromide
as phase transfer catalyst. In vitro antibacterial and antifungal
study of the synthesized analogues revealed six of them to
show significant antibacterial and four to show significant antifungal
activity. Among them 3c and 6c show most significant
antibacterial activities with minimum inhibitory concentration
value 32 lg/mL against four bacterial strains. Ultra structural
studies of the microbes treated with 6c demonstrated deformation
of cell wall and cell agglomeration. The bisquinolines
exhibiting bacteriostatic or fungistatic activity may be developed
as newer antimicrobial agents.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1814/1/MEDICINAL_CHEMISTRY_RESEARCH___22__(_1)_94%2D104_2003[19].pdf
Sahu, Krishnendu B and Ghosh, Soma and Banerjee , Maitreyee and Maity, Arindam and Mondal, Shyamal and Paira , Rupankar and Saha , Pritam and Naskar, Subhendu and Hazra , Abhijit and Banerjee, Sukdeb and Samanta, Amalesh and Mondal, Nirup B (2013) Synthesis and in Vitro Study of Antibacterial, Antifungal Activities of some Novel Bisquinolines. Medicinal Chemistry Research, 22 (1). pp. 94-104.
 
Relation http://dx.doi.org/10.1007/s00044-012-0011-4
http://www.eprints.iicb.res.in/1814/