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Facile Synthesis of [1,2,3]-Triazole-Fused Isoindolines, Tetrahydroisoquinolines, Benzoazepines and Benzoazocines by Palladium-Copper Catalysed Heterocyclisation

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Title Facile Synthesis of [1,2,3]-Triazole-Fused Isoindolines, Tetrahydroisoquinolines,
Benzoazepines and Benzoazocines by Palladium-Copper Catalysed
Heterocyclisation
 
Creator Brahma, Kaushik
Achari, Basudeb
Chowdhury, Chinmay
 
Subject Chemistry
 
Description An elegant method for the synthesis of 1,2,3-triazoles
fused with five-, six-, seven- and eight-membered benzoheterocycles,
including isoindoline, tetrahydroisoquinoline, benzoazepine
and benzoazocine, has been developed via palladium-copper catalysed
reactions in one-pot. The broad scope of this reaction was illustrated
by effecting bis-heteroannulations, synthesis of uracil
derivatives of biological interest, and employment of acetylene gas
as an inexpensive substrate. The reactions are experimentally simple
and utilise easily accessible substrates of different types.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1822/1/SYNTHESIS%2DSTUTTGART___45_(_4)s_545%2D555;2013[1].pdf
Brahma, Kaushik and Achari, Basudeb and Chowdhury, Chinmay (2013) Facile Synthesis of [1,2,3]-Triazole-Fused Isoindolines, Tetrahydroisoquinolines, Benzoazepines and Benzoazocines by Palladium-Copper Catalysed Heterocyclisation. Synthesis, 45 (4). pp. 545-555.
 
Relation http://dx.doi.org/10.1055/s-0032-1316839;
http://www.eprints.iicb.res.in/1822/