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Synthesis of Polynuclear Heteroaromatics Mainly Based on Pyridine and Quinoline

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Title Synthesis of Polynuclear Heteroaromatics Mainly Based on Pyridine and Quinoline
 
Creator Paira, Rupankar
 
Subject Chemistry
 
Description The thesis embodies the results of studies on the “Synthesis of polynuclear
heteroaromatics mainly based on pyridine and quinoline”. Quinoline and pyridine
derivatives are a class of synthetic antibiotics with broad spectrum of antibacterial as
well as anti-malarial activities. The fused pyridine and quinoline derivatives are also
known to be effective in the treatment of autoimmune conditions (such as rhenumatoid
arthritis) with their anti inflammatory effects. Among the numerous structurally diverse
derivatives of pyridine and quinolines many show significant biological activity such as
quinine, morphine, and multifloramine. Hence, it is not surprising that this structural
motif is also an important component in many of today’s pharmaceuticals. Nevertheless,
the diversity of pyridine and quinoline as well as their biological and pharmaceutical
relevance is still motivating academic and industrial researchers to look for new and
improved syntheses for quinoline derivatives. Clearly, a number of practical methods
have been developed for the synthesis of pyridine and quinolines in the past century.
More recently, especially transition metal catalysis has become a powerful tool for
synthetic methodology but chemical and biological research has now presented a great
challenge to synthesize and optimise highly efficient and cost-effective synthetic routes
to some unique and novel biologically active substances.
 
Date 2012
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1844/1/Rupankar_Paira_%2D_Thesis.pdf
Paira, Rupankar (2012) Synthesis of Polynuclear Heteroaromatics Mainly Based on Pyridine and Quinoline. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1844/