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Mechanism of altered lipid metabolism in Leishmania donovani infection and it 's implication in the disease pathogenesis

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Title Mechanism of altered lipid metabolism in Leishmania donovani infection and it 's implication in the disease pathogenesis
 
Creator Ghosh, June
 
Subject Infectious Diseases and Immunology
Molecular & Human Genetics
 
Description Leishmaniasis is a broad spectrum disease including visceral, cutaneous, mucocutaneous and
post kala azar dermal forms. Visceral Leishmaniasis (VL) caused by the obligate intracellular
protozoan species Leishmania donovani (Ld)(Old World) and Leishmania infantum(Li)(New
world) is the most fatal of all clinical manifestations (Murray, 2005). LD mainly affects
Mediterranean countries and parts of Indian subcontinent,the worst victim being Bihar and parts
of West Bengal. In Bihar alone, 44 million people of 28 districts and about 3.5 million people of
West Bengal are at a risk of Kala azar (WHO, 1993). The most frightening part of the new
incidences is that majority of the cases of Kala-azar have been reported to be unresponsive to
antimonial therapy (Sundar, 2006).
Sandfly vector responsible for transmission of leishmaniasis are divided in two genera:
Phlebotomus in the Old World and Lutzomyia in the New World (Killick-Kendrick et al,1990).
In India, Phlebotomus argentipes is the primary vector, but there are reports of P. papatasi as a
secondary vector (Rassi et al, 2011).
The parasite resides in spleen and liver leading to a condition known as hepatospleenomegaly
characterised by the enlargement of spleen and liver with severe fever and weight loss (Reiner,
1982).
 
Date 2012
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1846/1/JUNE_GHOSH_(Thesis).pdf
Ghosh, June (2012) Mechanism of altered lipid metabolism in Leishmania donovani infection and it 's implication in the disease pathogenesis. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1846/