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Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3- Dipolar Cycloaddition Reaction Under Microwave Irradiation
EPrints@IICB
View Archive Info| Field | Value | |
| Title |
Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3- Dipolar Cycloaddition Reaction Under Microwave Irradiation |
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| Creator |
Hazra, Abhijit
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| Subject |
Chemistry
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| Description |
Dispiro-pyrrolidino/pyrrolizidino fused oxindoles/acenaphthoquinones have been derived from andrographolide via azomethine ylide cycloaddition to the conjugated double-bond under microwave (MW) irradiation. The reactions are chemo-, stereo-, and regioselective in nature. Change in amino acid from sarcosine/N-benzyl glycine to L-proline changes the regiochemistry. A representative library of 40 compounds along with in vitro anticancer evaluation is reported. |
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
application/pdf |
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| Identifier |
http://www.eprints.iicb.res.in/1861/1/ACS_COMBINATORIAL_SCIENCE___15_(_1)_41%2D48;2013[35].pdf
http://www.eprints.iicb.res.in/1861/2/ACS_COMBINATORIAL_SCIENCE___15_(_1)_41%2D48;2013[35].pdf Hazra, Abhijit (2013) Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3- Dipolar Cycloaddition Reaction Under Microwave Irradiation. American Chemical Societ, 15 (1). pp. 41-48. |
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| Relation |
http://dx.doi.org/10.1021/co3001154
http://www.eprints.iicb.res.in/1861/ |
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