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Syntheses of Biologically Active Oligosaccharides and Carbohydrate Based Aza-heterocycles

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Title Syntheses of Biologically Active Oligosaccharides and
Carbohydrate Based Aza-heterocycles
 
Creator Sarkar, Swarbhanu
 
Subject Chemistry
 
Description The scientific research concerning lipopolysaccharides, lipooligosaccharides,
oligosaccharides and glycoconjugates etc. have gained momentum and is developing
rapidly in a most exciting manner during the past decade. Glycoconjugates represent an
important class of compounds that carry significant biological information and are
responsible for various biological recognition processes, virulence factors, immunity etc.
The thesis entitled ‘Syntheses of Biologically Active Oligosaccharides and
Carbohydrate Based Aza-heterocycles’ includes the synthesis of a unique mannopentasaccharie
having a specific linkage pattern which can bind with the two binding
domains of a lectin isolated from Musa paradisiaca (banana).
The extensive use of aza-heterocyclic compounds in the pharmaceutical industry is
attributed to the significant biological activity of these molecules. However, their use
becomes limited due to low solubility in water. Thus synthesis of water-soluble azaheterocyclic
compounds, having biological activity in a highly efficient and cost-effective
manner is a great challenge. Carbohydrate based aza-derivatives can be a suitable
alternative.
 
Date 2012
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1870/1/Swarbhanu_Sarkar_Thesis_2012.pdf
Sarkar, Swarbhanu (2012) Syntheses of Biologically Active Oligosaccharides and Carbohydrate Based Aza-heterocycles. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1870/