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Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts

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Title Effects of interferons and interleukin 2 on
natural killing of cytomegalovirus-infected fibroblasts
 
Creator Bandyopadhyay, Santu
Miller, D S
Matsumoto-Kobayashi, M
Clark, S C
Starr, S E
 
Subject Infectious Diseases and Immunology
 
Description The ability of nonadherent peripheral blood mononuclear cells of normal individuals to
lyse noninfected and cytomegalovirus (CMV)-infected human fibroblasts was enhanced
by preincubation with recombinant human alpha interferon (LX-rIFN) or beta (f3-rIFN). In
contrast, recombinant human gamma IFN (y-rIFN) augmented natural killing (NK)
against both targets relatively poorly. Recombinant or natural human interleukin 2(IL-2)
also augmented NK against noninfected and CMV-infected targets. Augmentation ofNK
by IFN or IL-2 could be blocked by the addition of corresponding antisera. IL-2-
enhanced NK against CMV-infected targets was usually independent of o-IFN production
 
Date 1987
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1898/1/%2CClin._exp._Immunol.__67%2C_372%2D382;1987.pdf
Bandyopadhyay, Santu and Miller, D S and Matsumoto-Kobayashi, M and Clark, S C and Starr, S E (1987) Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts. Clinical experimental Immunology, 67. pp. 372-382.
 
Relation http://www.eprints.iicb.res.in/1898/