Record Details

Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Natural killing of fibroblasts infected with low-passage
clinical isolates of human cytomegalovirus
 
Creator Bandyopadhyay, Santu
Hee oh, , Sung
Michelson, Susan
Miller, Deborah S
 
Subject Infectious Diseases and Immunology
 
Description Fibroblasts infected with most low-passage clinical isolates of human cytomegalovirus (CMV) were
as susceptible to lysis by human natural killer (NK) cells as high passage AD-169-infected fibroblasts.
NK lysis occurred despite the absence of detectable CMV-specific late membrane antigen(s) on the
majority ofthe target cells infected with most of the low passage strains. The magnitude ofNK lysis of
different CMV-infected target cells did not correlate with their ability to induce IFN-a. NK cellmediated
lysis of cells infected with low-passage clinical isolates ofCMV required both NK cells and
HLA-DR+ accessory cells, as previously shown for AD-169-infected target cells.
 
Date 1988
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1904/1/Clin._exp._Immunol.__73%2C_11%2D16;1988.pdf
Bandyopadhyay, Santu and Hee oh, , Sung and Michelson, Susan and Miller, Deborah S (1988) Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus. Clinical experimental Immunology, 73. pp. 11-16.
 
Relation http://www.eprints.iicb.res.in/1904/