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Dendritic cells and IFN-a-producing cells are two functionally distinct non-B,non-monocytic HLA-DR+ cell subsets in human peripheral blood

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Title Dendritic cells and IFN-a-producing cells are two functionally distinct non-B,non-monocytic HLA-DR+ cell subsets in human peripheral blood
 
Creator Chehimi, J
Kawashima, H
Miller, D S
Starr, S E
Trinchierit , G
Perussia, B
Bandyopadhyay, Santu
 
Subject Infectious Diseases and Immunology
 
Description At least two distinct HLA-DR+ cell subsets lacking surface markers specific for B cells, monocytes or
other known lineages are present in human peripheral blood. One subset is non-adherent to plastic,
produces interferon-alpha (IFN-a) when incubated with cytomegalovirus-infected target cells and
provides an accessory function required for natural killer (NK) cell-mediated lysis of such cells. These
non-adherent HLA-DR+ cells express the surface antigen recognized by antibody anti-D44 and do
not stimulate mixed leucocyte reaction (MLR). The other HLA-DR+ cell subset is loosely adherent
to plastic, produces only minimal levels of IFN-a when incubated with cytomegalovirus-infected
target cells and does not provide the accessory function required for NK cell-mediated lysis of such
cells. These HLA-DR+ cells stimulate a strong MLR, do not express D44 antigen and meet the
criteria of dendritic cells (DC) morphologically and functionally
 
Publisher Blackwell Publishing
 
Date 1989
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1906/1/Immunology%2C__68%2C_486%2D490;1989.pdf
Chehimi, J and Kawashima, H and Miller, D S and Starr, S E and Trinchierit , G and Perussia, B and Bandyopadhyay, Santu (1989) Dendritic cells and IFN-a-producing cells are two functionally distinct non-B,non-monocytic HLA-DR+ cell subsets in human peripheral blood. Immunology, 68. pp. 486-490.
 
Relation http://www.eprints.iicb.res.in/1906/