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Vibrio cholerae O395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses

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Title Vibrio cholerae O395 Outer Membrane Vesicles Modulate
Intestinal Epithelial Cells in a NOD1 Protein-dependent
Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell
Responses
 
Creator Chatterjee, Debashree
Chaudhuri, Keya
 
Subject Molecular & Human Genetics
 
Description Vibrio cholerae, the etiologic agent of cholera, secretes outer membrane vesicles (OMVs) that are internalized
into host cells. OMVs activate an inflammatory response in intestinal epithelial cells (ECs) via a NOD1-dependent pathway thatactivates dendritic cells (DCs) and promotes T cell polarization toward Th2/Th17 responses.
OMVs stimulate EC-DC cross-talk in generating an inflammatory response.Findings are important for the development of efficient vaccine strategies with OMVs
 
Publisher American Society for Biochemistry and Molecular Biology
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1928/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY___288__(_6)4299%2D4309;2013[76].pdf
Chatterjee, Debashree and Chaudhuri, Keya (2013) Vibrio cholerae O395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses. The Journal of Biological Chemistry, 288 (6). pp. 4299-4309.
 
Relation http://dx.doi.org/10.1074/jbc.M112.408302
http://www.eprints.iicb.res.in/1928/