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Tricarbonyltechnetium(I) and tricarbonylrhenium(I) complexes of amino acids: crystal and molecular structure of a novel cyclic dimeric Re(CO)3-amino acid complex comprised of the OON donor atom set of the tridentate ligand

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Title Tricarbonyltechnetium(I) and tricarbonylrhenium(I)
complexes of amino acids: crystal and molecular
structure of a novel cyclic dimeric Re(CO)3-amino acid
complex comprised of the OON donor atom set of the
tridentate ligand
 
Creator Nayak, Dipak Kumar
Halder, Kamal Krishna
Baishya, Rinku
Sen, Tuhinadri
Mitra, Partha
Chatterjee Debnath, Mita
 
Subject Infectious Diseases and Immunology
 
Description Radiolabeled complexes of monoamino polycarboxylic, polyamino monocarboxylic and thiol containing
amino acid ligands were prepared from a fac-[99mTc(CO)3(H2O)3]+ precursor.The overall radiochemical
yield was 94–98%. The complexes exhibited substantial in vitro and in vivo stability. The corresponding Re(I)
complexes of the ligands DAPA, Asp and CysH were prepared and characterized by means of IR, NMR, and
MS spectroscopic studies, as well as X-ray crystallography (for those containing D,L-DAPA and D,L-Asp). The
rhenium complexes have been structurally correlated with the technetium complexes by means of HPLC
studies. The reaction of Re(CO)5Cl with D,L-Asp in presence of triethylamine led to the formation of a new
class of cyclic dimeric complexes formed by the OON donor atom set of the tridentate ligands. The amino
carboxylate ligand system formed well defined complexes with a fac-[M(CO)3(H2O)3]+ core and shows
good promise in 99mTc(CO)3 tracer development
 
Publisher Royal Society of Chemistry
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1960/1/DALTON_TRANSACTIONS__Volume_42__(37)___Pages_13565%2D13575;2013[127].pdf
Nayak, Dipak Kumar and Halder, Kamal Krishna and Baishya, Rinku and Sen, Tuhinadri and Mitra, Partha and Chatterjee Debnath, Mita (2013) Tricarbonyltechnetium(I) and tricarbonylrhenium(I) complexes of amino acids: crystal and molecular structure of a novel cyclic dimeric Re(CO)3-amino acid complex comprised of the OON donor atom set of the tridentate ligand. Dalton Transactions, 42 (37). pp. 13565-13575.
 
Relation http://dx.doi.org/10.1039/c3dt50928a
http://www.eprints.iicb.res.in/1960/