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Structural characterization of Type III Secretion System Structural characterization of Type III Secretion Systemrelated translocator and effector from Pseudomonas aeruginosa. .

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Title Structural characterization of
Type III Secretion System
Structural characterization of Type III Secretion Systemrelated translocator and effector from Pseudomonas aeruginosa.
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Creator Dey, Supratim
 
Subject Structural Biology & Bioinformatics
 
Description Pseudomonas aeruginosa, a Gram-negative pathogen utilizes a specialized set of Type III Secretion System (T3SS) translocator and effector proteins to establish virulence in the host
cell. An understanding of these pathogenic factors that play a key role in the establishment
and maintenance of bacterial pathogenicity are thus, of immense importance, and are likely
the interest of study of several research groups.
The T3SS encoding “translocator operon” of P. aeruginosa consists of a major translocator
protein PopB, minor translocator protein PopD and their cognate chaperone Pcpresent a comprehensive study of PopB structure, its interaction with PcrH and their
associated pH-based structural and functional changes. The pH-dependent studies indicate that PcrH not only provides structural support to the ordered molten globule PopB in
complex but also undergoes conformational change to assist PopB to pass through.SPR studies determine the terminal domains of PopB to be involved in hydrophobic
interaction with PcrH as well as maintain the oligomerisation of translocator complex
 
Date 2013
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1999/1/SupratimThesis_Final.pdf
Dey, Supratim (2013) Structural characterization of Type III Secretion System Structural characterization of Type III Secretion Systemrelated translocator and effector from Pseudomonas aeruginosa. . PhD thesis, Calcutta University .
 
Relation http://www.eprints.iicb.res.in/1999/