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IL-4 contributes to failure, and colludes with IL-10 to exacerbate Leishmania donovani infection following administration of a subcutaneous leishmanial antigen vaccine

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Title IL-4 contributes to failure, and colludes with IL-10
to exacerbate Leishmania donovani infection following administration of a subcutaneous leishmanial antigen vaccine
 
Creator Bhowmick, Sudipta
Ravindran, Rajesh
Ali, Nahid
 
Subject Infectious Diseases and Immunology
 
Description Visceral leishmaniasis caused by the protozoan parasite Leishmania donovani complex is a potentially
fatal disease if left untreated. Few treatment options exist and are toxic, costly and ineffective against resistant
strains. Thus a safe and efficacious vaccine to combat this disease is needed. Previously, we reported that intraperitoneal
administration of leishmanial antigens (LAg) entrapped in liposomes conferred protection to BALB/c mice against
L. donovani challenge infection. However, this vaccine failed to protect mice when administered subcutaneously. We
therefore evaluated whether formulation of LAg in combination with two commonly used human-compatible
adjuvants, alum and saponin, could improve the protective efficacy of subcutaneously administered LAg, to a level
comparable to that of the intraperitoneal liposomal vaccination
 
Publisher BioMed Central
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2011/1/BMC_MICROBIOLOGY__V_14___Article_Number_8_;2014(18).pdf
Bhowmick, Sudipta and Ravindran, Rajesh and Ali, Nahid (2014) IL-4 contributes to failure, and colludes with IL-10 to exacerbate Leishmania donovani infection following administration of a subcutaneous leishmanial antigen vaccine. BMC Microbiology, 14 (8).
 
Relation http://www.eprints.iicb.res.in/2011/