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Mitochondrial Genome Variations among Arsenic Exposed Individuals and Potential Correlation with Apoptotic Parameters

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Title Mitochondrial Genome Variations among Arsenic Exposed Individuals and Potential Correlation with Apoptotic Parameters
 
Creator Sinha, Sharmistha
Giri, Ashok K.
Chowdhury, Rukhsana
Ray, Kunal
 
Subject Infectious Diseases and Immunology
Molecular & Human Genetics
 
Description Exposure to arsenic (As) causes serious health
hazards. Therefore, there is a sustained effort to
understand the molecular basis of the risk posed
by the toxicant. It has been reported that apoptotic
changes ensue on exposure to As. To
investigate the molecular basis of such changes,
we sequenced the entire mitochondrial (mt)
genome from PBMC of a subset of these individuals
(As-exposed516 and unexposed518) using
Affymetrix platform. Our analysis revealed that
As exposure does not induce large-scale mt-DNA
variations, but that specific deleterious changes
could induce mt dysfunction. A Glu115Ter mutation
as well as 17 other in silico predicted deleterious
variants were identified exclusively in exposed individuals. The number of variants in mt Complex I in As-exposed individuals was positively correlated with their respective intracellular ROS level. In addition, the extent of potentially damaging variants in As-exposed individuals had significant positive correlation to the degree of
G0/G1 cell cycle arrest. Environ. Mol. Mutagen.55:70–76, 2014.
 
Publisher Wiley Online
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2020/1/ENVIRONMENTAL_AND_MOLECULAR_MUTAGENESIS__V_55(_1)_70%2D76_;2014(34).pdf
Sinha, Sharmistha and Giri, Ashok K. and Chowdhury, Rukhsana and Ray, Kunal (2014) Mitochondrial Genome Variations among Arsenic Exposed Individuals and Potential Correlation with Apoptotic Parameters. Environmental and MolecularMutagenesis, 55 (1). pp. 70-76.
 
Relation http://dx.doi.org/10.1002/em.21828
http://www.eprints.iicb.res.in/2020/