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Antibacterial and antiviral evaluation of sulfonoquinovosyldiacylglyceride: a glycolipid isolated from Azadirachta indica leaves

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Title Antibacterial and antiviral evaluation of
sulfonoquinovosyldiacylglyceride: a glycolipid isolated
from Azadirachta indica leaves
 
Creator Bharitkar, Y.P.
Bathini, S.
Ojha, D.
Ghosh, S.
Mukherjee, H.
Kuotsu, K.
Chattopadhyay, D.
Mondal, Nirup B
 
Subject Chemistry
 
Description Assessment of antibacterial as well as antiherpes virus activity of sulfonoquinovosyldiacylglyceride (SQDG), a glycolipid, isolated from the leaves of Azadirachta indica has been described. Antimicrobial activity was evaluated
against Gram-positive, Gram-negative bacteria and herpes simplex virus. SQDG showed significant inhibitory activity against Salmonella typhi and two isolates of Shigella dysenteriae with MIC values 32 lg ml �1, while three isolates of Salm. typhi, Escherichia coli and Vibrio cholerae were inhibited at 64 lg ml �1 and have shown zone diameter ranging from 6�2 to 12�3 mm. The growth kinetics study of SQDG on Salm. typhi and Sh. dysenteriae revealed that the growths were completely inhibited at their MIC values within 24 h of exposure. Interestingly, SQDG inhibits herpes simplex virus (HSV) type 1 and 2 with the EC50 of 9�1 and 8�5 lg ml �1, compared with acyclovir (2�2 and
2�8 lg ml �1 against HSV-1 and HSV-2). The selectivity index (SI) was found to be 12�4 against HSV-1 and 13�41 with HSV-2. Furthermore, the expression of proinflammatory cytokines of HSV-infected and SQDG-treated macrophages
using ELISA kit revealed that SQDG significantly downregulated the production of TNF-a, IL-1b, IL-12 and IL-6.
 
Publisher Blackwell Publishing
 
Date 2014
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1111/lam.12174
http://www.eprints.iicb.res.in/2025/
 
Identifier Bharitkar, Y.P. and Bathini, S. and Ojha, D. and Ghosh, S. and Mukherjee, H. and Kuotsu, K. and Chattopadhyay, D. and Mondal, Nirup B (2014) Antibacterial and antiviral evaluation of sulfonoquinovosyldiacylglyceride: a glycolipid isolated from Azadirachta indica leaves. Letters In Applied Microbiology, 58 (2). pp. 184-189. ISSN 0266-8254