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Synthesis of Polynuclear Heteroaromatics Using Green Chemistry Protocols and their Bio-Evaluation

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Title Synthesis of Polynuclear Heteroaromatics Using Green Chemistry Protocols and their Bio-Evaluation
 
Creator Banerjee, Maitreyee
 
Subject Chemistry
 
Description The work embodied in this thesis describes the facile synthesis of nitrogen containing heterocyclic compounds through facile and environment friendly protocol and evaluation of their bioactive potential. Chapter I includes a brief discussion on the development of spermicides from different natural and synthetic sources. The review is a compilation of the promising molecules and even extracts, and includes an outline of the basic physiology behind the bioactivity. Chapter II describes the facile one-pot green methodology to synthesize a series of quinoline derivatives starting from 8-OH-quinoline using di-bromo alkanes as reactant. The synthesized compounds were assessed for their sperm-immobilizing as well as microbicidal activities by various standardized assays. Mode of actions was also investigated by electron microscopic imaging and biochemical assays. Chapter III illustrates the synthesis of 7-Aryl substituted furo[3,2-h]quinoliniums from 5-chloro-8-hydroxy-7-iodo-quinoline in two steps through a tandem Sonogashira alkynylation-cyclization pathway using aryl acetylenes, followed by quaternisation reaction with alkyl halides under microwave irradiation. These compounds too have been screened and investigated for spermicidal activity.Chapter IV narrates the Friedel-Crafts reaction of differently substituted anilines with ninhydrin in presence of molecular iodine at ambient temperature, constituting a facile, cost effective, and regioselective synthesis of a series of 2-mono/2,2-bis-(amino-phenyl)-indane-1,3-dione derivatives. These compounds were screened for Microbicidal activities against quite a few number of bacterial and fungal strains.
 
Date 2014
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2075/1/Maitreyee_Banerjee%2C_Ph.D._Thesis.pdf
Banerjee, Maitreyee (2014) Synthesis of Polynuclear Heteroaromatics Using Green Chemistry Protocols and their Bio-Evaluation. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/2075/