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Role of Apoptosis, Autophagy and Mitochondrial Dysfunction in Anti Leukemic Activities of Andrographolide and indole derivatives

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Title Role of Apoptosis, Autophagy and Mitochondrial Dysfunction in Anti Leukemic Activities of Andrographolide and indole derivatives
 
Creator Kumar, Deepak
 
Subject Cancer Biology and Inflammatory Disorder Division
Chemistry
 
Description Cancer, the medical term of which is malignant neoplasm, is a class of disease in which a group of cells display uncontrolled growth (division beyond normal limits), invasion (intrusion on and destruction of adjacent tissues), and metastasis (spread to other locations in the body via lymph or blood). These three properties differentiate them from benign tumors which do not intrude into other regions (Merlo et al., 2006). According to the World Health Organization, cancer is the leading cause of death in developed countries and is second to cardiovascular diseases in developing countries. The total number of registered cases of cancer in the year 2010 was 979,786 of which 555,000 were cases of reported deaths (Takiar et al., 2010). International Agency for Research on Cancer estimates a whopping number of 16 million new cases of cancer by the year 2020. WHO also projects that cancer will soon replace ischemic heart disease as the overall leading cause of death worldwide (IARC press release, 2010-2020).
 
Date 2014
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2078/1/Thesis_Deepak_Kumar.pdf
Kumar, Deepak (2014) Role of Apoptosis, Autophagy and Mitochondrial Dysfunction in Anti Leukemic Activities of Andrographolide and indole derivatives. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/2078/