Record Details

Current diagnosis and treatment of visceral leishmaniasis

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Current diagnosis and treatment of visceral leishmaniasis
 
Creator Mondal, Smriti
Bhattacharya, Pradyot
Ali, Nahid
 
Subject Infectious Diseases and Immunology
 
Description Human visceral leishmaniasis (VL), a potentially fatal disease, is most prevalent in the Indian subcontinent, East Africa and South America. Definite diagnosis and effective treatment are the primary needs for the control of VL. Diagnosis of VL has typically relied on microscopic
examination of bone marrow/splenic aspirate, but serology and molecular methods are now better alternatives. The conventional drugs for treatment of VL have limitations including unresponsiveness, relapse, specific toxicities and parenteral administration lasting for long durations. Moreover, they are less effective in HIV–VL-coinfected patients. Registration of miltefosine and paromomycin, and preferential pricing of AmBisome has offered more choices
for monotherapy and combination therapy for VL. Combination therapy will increase treatment efficacy and prevent the development of resistance. In addition, active case finding and vector control strategies will also have a positive impact in the control of VL. This article critically
addresses the currently available diagnostic and treatment regimens for the control of VL.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2099/1/Review_Final_Version.pdf
Mondal, Smriti and Bhattacharya, Pradyot and Ali, Nahid (2010) Current diagnosis and treatment of visceral leishmaniasis. Expert Reviews. pp. 1-26. ISSN 1476-0584
 
Relation http://www.eprints.iicb.res.in/2099/