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Involvement and interactions of different immune cells and their cytokines in human visceral leishmaniasis

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Title Involvement and interactions of different immune cells
and their cytokines in human visceral leishmaniasis
 
Creator Bhattacharya, Pradyot
Ali, Nahid
 
Subject Infectious Diseases and Immunology
 
Description Visceral leishmaniasis (VL) or kala-azar, a disseminated infection of the lymphoreticular system of the body, is marked by severe defect in immune system of the host. Successful cure of VL depends on the immune status of the host in combination with the effects of the antileishmanial drugs. The rationale approach towards eradication of this disease would be to potentiate the immune functioning of the host in addition to parasite killing. This review deals with different aspects of adaptive and innate immune
responses and explores their role in protection or pathogenesis of VL. IL-10 has emerged as the principal cytokine responsible
for disease pathogenesis, although evidences regarding its source during active VL remain inconclusive. On the other hand, IFNγ,
under the influence of IL-12, is mostly correlated with healing of the disease. Chemokines are important in mounting cell-mediated
immune response as they can prevent parasite invasion in association with cytokines. Different types of T cells like CD4, CD8
and NK T cells also contribute to the immunology of this disease. In spite of conflicting reports, the role of regulatory T cells in
VL pathogenesis is important. Recently discovered Th17 subset and its different members have been reported to perform diverse
functions in the course of VL and leishmaniasis as a whole. Innate immune responses, depending on the cell types, are essential
in early parasite detection and subsequent development of an efficient NK cell response. Immunotherapy targeting IL-10 could
be looked upon as an interesting option for the treatment of VL
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2101/1/Revista_da_Sociedade_Brasileira_de_Medicina_Tropical%2C2014.pdf
Bhattacharya, Pradyot and Ali, Nahid (2012) Involvement and interactions of different immune cells and their cytokines in human visceral leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical. pp. 1-7.
 
Relation http://dx.doi.org/10.1590/0037-8682-0022-2012
http://www.eprints.iicb.res.in/2101/