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Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer

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Title Anomalous altered expressions of downstream gene-targets in
TP53-miRNA pathways in head and neck cancer
 
Creator Mitra, Sanga
Mukherjee, Nupur
Das, Smarajit
Das, Pijush K
Panda, Chinmay Kumar
Chakrabarti, Jayprokas
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description The prevalence of head and neck squamous cell carcinoma, HNSCC, continues to grow. Change in the expression of TP53 in HNSCC affects its downstream miRNAs and their gene targets, anomalously altering the expressions of the five genes, MEIS1, AGTR1, DTL, TYMS and BAK1. These expression alterations follow the repression of TP53 that upregulates miRNA-107, miRNA- 215, miRNA-34 b/c and miRNA-125b,
but downregulates miRNA-155. The above five so far unreported genes are the targets of these miRNAs. Meta-analyses of microarray and RNA-Seq data followed by qRT-PCR validation unravel these new ones in HNSCC. The regulatory roles of TP53 on miRNA-155 and miRNA-125b differentiate the expressions of AGTR1 and BAK1in HNSCC vis-a`-vis other carcinogenesis. Expression changes alter cell cycle regulation, angiogenic and blood cell formation, and apoptotic modes in affliction. Pathway analyses establish the resulting systems-level functional and mechanistic insights into the etiology of HNSCC.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2164/1/SCIENTIFIC_REPORTS__V_4_____Article_Number_6280;2014[44].pdf
Mitra, Sanga and Mukherjee, Nupur and Das, Smarajit and Das, Pijush K and Panda, Chinmay Kumar and Chakrabarti, Jayprokas (2014) Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer. SCIENTIFIC REPORTS, 4 (6280).
 
Relation http://dx.doi.org/10.1038/srep06280
http://www.eprints.iicb.res.in/2164/