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Flavone-resistant Leishmania donovani Overexpresses LdMRP2 Transporter in the Parasite and Activates Host MRP2 on Macrophages to Circumvent the Flavone-mediated Cell Deat

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Title Flavone-resistant Leishmania donovani Overexpresses LdMRP2
Transporter in the Parasite and Activates Host MRP2 on
Macrophages to Circumvent the Flavone-mediated Cell Deat
 
Creator Chowdhury, Sayan
Mukhopadhyay, Rupkatha
Saha, Sourav
Mishra, Amartya
Sengupta, Souvik
Roy, Syamal
Majumder, Hemanta K
 
Subject Infectious Diseases and Immunology
 
Description Leishmania donovani adopts several defense mechanisms to become resistant to antileishmanial agents. Laboratory-grown flavone (baicalein)-resistant parasites exhibit efflux of drug by LdABCC2 transporter. Inside the host
macrophage, this parasite up-regulates host MRP2 transporter by an Nrf2-dependent pathway. Resistant Leishmania parasite exploits ABC transporter in the parasite and inside the host.
 
Publisher American Society for Biochemistry and Molecular Biology
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2174/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY__V289(_23_)16129%2D16147_;2014[90].pdf
Chowdhury, Sayan and Mukhopadhyay, Rupkatha and Saha, Sourav and Mishra, Amartya and Sengupta, Souvik and Roy, Syamal and Majumder, Hemanta K (2014) Flavone-resistant Leishmania donovani Overexpresses LdMRP2 Transporter in the Parasite and Activates Host MRP2 on Macrophages to Circumvent the Flavone-mediated Cell Deat. The Journal of Biological Chemistry, 289 (23). pp. 16129-16147.
 
Relation http://dx.doi.org/10.1074/jbc.M113.539742
http://www.eprints.iicb.res.in/2174/