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Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties

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Title Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties
 
Creator Rana, Bidyut Kumar
Nandy, Abhishek
Bertolasi, Valerio
Bielawski, Christopher W
Das Saha, Krishna
Dinda, Joydev
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description A novel Au(III)−N-heterocyclic carbene organometallic
complex supported by two N-heterocyclic carbene (NHC)
ligands was synthesized from Au(SMe2)Cl and 1-methyl-2-pyridin-2- yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate via a Ag intermediate. X-ray crystallography revealed the first example of a square planar geometry adopted by a Au(III) species stabilized by two NHCs and two chloride ligands. The aforementioned Au(I)− and Au(III)−NHC complexes were found to be more potent than cisplatin against the HCT 116, HepG2, A549, and MCF7 cell lines.
 
Publisher American Chemical Society
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2180/1/ORGANOMETALLICS__V_33_(_10)_2544%2D2548_;2014[100].pdf
Rana, Bidyut Kumar and Nandy, Abhishek and Bertolasi, Valerio and Bielawski, Christopher W and Das Saha, Krishna and Dinda, Joydev (2014) Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties. Organometallics, 33 (10). pp. 2544-2548.
 
Relation http://dx.doi.org/10.1021/om500118x
http://www.eprints.iicb.res.in/2180/