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Modular Multiantigen T Cell Epitope–Enriched DNA Vaccine Against Human Leishmaniasis

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Title Modular Multiantigen T Cell Epitope–Enriched DNA
Vaccine Against Human Leishmaniasis
 
Creator Das, Shantanabha
Freier, Anja
Boussoffara, Thouraya
Das, Sushmita
Oswald, Detlef
Losch, Florian O.
Selka, Melanie
Sierra, Nina Sacerdoti-
Schönian, Gabriele
Wiesmüller, Karl-Heinz
Seifert, Karin
Schroff, Matthias
Juhls, Christiane
Jaffe, Charles L.
Roy, Syamal
Das, Pradeep
Louzir, Hechmi
Croft, Simon L.
Modabber, Farrokh
Walden, Peter
 
Subject Infectious Diseases and Immunology
 
Description The leishmaniases are protozoal diseases that severely affect large populations in tropical and subtropical regions.There are only limited treatment options and preventative measures. Vaccines will be important for prevention, control and elimination of leishmaniasis, and could reduce the transmission and burden of disease in endemic populations.We report the development of a DNA vaccine against leishmaniasis that induced T cell–based immunity and is a candidate for clinical trials. The vaccine antigens were selected as conserved in various Leishmania species, different endemic regions, and over time. They were tested with T cells from individuals cured of leishmaniasis, and shown to be immunogenic and to induce CD4+ and CD8+ T cell responses in genetically diverse human populations of different endemic regions. The vaccine proved protective in a rodent model of infection. Thus, the immunogenicity of candidate vaccine antigens in human populations of endemic regions, as well as proof of principle for induction of specific immune responses
and protection against Leishmania infection in mice, provides a viable strategy for T cell vaccine development.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2182/1/SCIENCE_TRANSLATIONAL_MEDICINE__V_6__(234_)____Article_Number_234ra56;2014[119].pdf
Das, Shantanabha and Freier, Anja and Boussoffara, Thouraya and Das, Sushmita and Oswald, Detlef and Losch, Florian O. and Selka, Melanie and Sierra, Nina Sacerdoti- and Schönian, Gabriele and Wiesmüller, Karl-Heinz and Seifert, Karin and Schroff, Matthias and Juhls, Christiane and Jaffe, Charles L. and Roy, Syamal and Das, Pradeep and Louzir, Hechmi and Croft, Simon L. and Modabber, Farrokh and Walden, Peter (2014) Modular Multiantigen T Cell Epitope–Enriched DNA Vaccine Against Human Leishmaniasis. ScienceTranslational Medicine, 6 (234). 234ra56.
 
Relation http://dx.doi.org/10.1126/scitranslmed.3008222
http://www.eprints.iicb.res.in/2182/