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Interaction of Ab peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells

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Title Interaction of Ab peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells
 
Creator Saha, Abhijit
Mohapatra, Saswat
Kurkute, Prashant
Jana, Batakrishna
Mondal, Prasenjit
Bhunia, Debmalya
Ghosh, Subhajit
Ghosh, Surajit
 
Subject Chemistry
 
Description We report in this work that the Ab peptide directly interacts with tubulin close to the vinblastine and GTP/GDP binding site, inhibits the tubulin polymerization rate, induces tubulin aggregation, causes cell shrinking, enhances Mad2, BubR1, p53, and p21 activation in MCF7
cells and induces the apoptotic death of A549, HeLa and MCF7 cells.
 
Publisher Royal Society of Chemistry
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2209/1/CHEMICAL_COMMUNICATIONS__V._51_(_12_)2249%2D2252_;2012[99].pdf
Saha, Abhijit and Mohapatra, Saswat and Kurkute, Prashant and Jana, Batakrishna and Mondal, Prasenjit and Bhunia, Debmalya and Ghosh, Subhajit and Ghosh, Surajit (2015) Interaction of Ab peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells. Chemical Communications, 51 (12). pp. 2249-2252.
 
Relation http://dx.doi.org/10.1039/c4cc09390a
http://www.eprints.iicb.res.in/2209/