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Doubly chloro bridged dimeric copper(II) complex: magneto-structural correlation and anticancer activity

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Title Doubly chloro bridged dimeric copper(II) complex: magneto-structural correlation and anticancer activity
 
Creator Sikdar, Yeasin
Modak, Ritwik
Bose, Dipayan
Banerjee, Saswati
Bieńko, Dariusz
Zierkiewicz, Wiktor
Bieńko, Alina
Das Saha, Krishna
Goswami, Sanchita
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description We have synthesized and structurally characterized a new doubly chloro bridged dimeric copper(II) complex, [Cu2(μ-Cl)2(HL)2Cl2] (1) based on a Schiff base ligand, 5-[(pyridin-2-ylmethylene)-amino]-pentan-1-ol). Single crystal X-ray diffraction shows the presence of dinuclear copper(II) centres in a square pyramidal geometry linked by obtuse double chloro bridge. The magnetic study illustrated that
weak antiferromagnetic interactions (J = −0.47 cm−1) prevail in complex 1 which is well supported by magneto-structural correlation. This compound adds to the library of doubly chloro bridged copper(II) complexes in the regime of spin state cross over. DFT calculations have been conducted within a brokensymmetry(BS) framework to investigate the exchange interaction further which depicts that the approximate spin projection technique yields the best corroboration of the experimental J value. Spin density
plots show the presence of an ∼0.52e charge residing on the copper atom along with a substantial charge on bridging and peripheral chlorine atoms. The potential of complex 1 to act as an anticancer agent is thoroughly examined on a series of liver cancer cell lines and screening shows the HepG2 cell line exhibits maximum cytotoxicity by phosphatidyl serine exposure in the outer cell membrane associated with ROS generation and mitochondrial depolarization with increasing time in the in vitro
model system.
 
Publisher Royal Society of Chemistry
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2213/1/DALTON_TRANSACTIONS__V._44__(_19_)_8876%2D8888_;2015[85].pdf
Sikdar, Yeasin and Modak, Ritwik and Bose, Dipayan and Banerjee, Saswati and Bieńko, Dariusz and Zierkiewicz, Wiktor and Bieńko, Alina and Das Saha, Krishna and Goswami, Sanchita (2015) Doubly chloro bridged dimeric copper(II) complex: magneto-structural correlation and anticancer activity. Dalton Transactions, 44 (19). pp. 8876-8888.
 
Relation http://dx.doi.org/10.1039/c5dt00752f
http://www.eprints.iicb.res.in/2213/