Record Details

Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata
 
Creator Bharitkar, Yogesh P
Hazra, Abhijit
Poduri, N.S. Apoorva
Ash, Anirban
Maulik, Prakas R.
Mondal, Nirup B
 
Subject Chemistry
 
Description Aerva lanata possesses various useful medicinal and pharmaceutical activities.Phytochemical investigation of the plant has now led to the isolation of a new
2a,3a,15,16,19-pentahydroxy pimar-8(14)-ene diterpenoid (1) together with 12 other known compounds identified as b-sitosterol (2), b-sitosterol-3-O-b-D-glucoside (3),
canthin-6-one (4), 10-hydroxycanthin-6-one (aervine, 5), 10-methoxycanthin-6-one (methylaervine, 6), b-carboline-1-propionic acid (7), 1-O-b-D-glucopyranosyl- (2S,3R,8E)-2-[(20R)-2-hydroxylpalmitoylamino]-8-octadecene-1,3-diol (8), 1-O-(b-Dglucopyranosyl)-(2S,3S,4R,8Z)-2-[(20R)-20-hydroxytetracosanoylamino]-8(Z)-octadene-1,3,4-triol (9), (2S,3S,4R,10E)-2-[(20R)-20-hydroxytetracosanoylamino]-10-octadecene-1,3,4-triol (10), 60-O-(400-hydroxy-trans-cinnamoyl)-kaempferol-3-O-b-Dglucopyranoside
(tribuloside, 11), 3-cinnamoyltribuloside (12) and sulfonoquinovosyldiacylglyceride (13). Among these, six compounds (8–13) are reported for the first
time from this plant. Cytotoxicity evaluation of the compounds against five cancer cell lines (CHO, HepG2, HeLa, A-431 and MCF-7) shows promising IC50 values for
compounds 4, 6 and 12.
 
Publisher Taylor & Francis
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2244/1/NATURAL_PRODUCT_RESEARCH__V._29___(_3__)_253%2D261_;2015[72].pdf
Bharitkar, Yogesh P and Hazra, Abhijit and Poduri, N.S. Apoorva and Ash, Anirban and Maulik, Prakas R. and Mondal, Nirup B (2015) Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata. Natural Product Research, 29 (3). pp. 253-261. ISSN 1478-6419
 
Relation http://dx.doi.org/10.1080/14786419.2014.971794
http://www.eprints.iicb.res.in/2244/