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Effects of Transient Hypoxia versus Prolonged Hypoxia on Satellite Cell Proliferation and Differentiation In Vivo

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Title Effects of Transient Hypoxia versus Prolonged Hypoxia on
Satellite Cell Proliferation and Differentiation In Vivo
 
Creator Jash, Sukanta
Adhya, Samit
 
Subject Molecular & Human Genetics
 
Description The microenvironment of the injury site can have profound effects on wound healing. Muscle injury results in ischemia leading to
short-termlocal hypoxia, but there are conflicting reports on the role of hypoxia on themyogenic programin vivo and in vitro. In our
rat model of mitochondrial restoration (MR), temporary upregulation of mitochondrial activity by a cocktail of organelle-encoded
RNAs results in satellite cell proliferation and initiation ofmyogenesis.We now report thatMR leads to a transient hypoxic response
in situ. Inhibition of hypoxia by lowering mitochondrial O2 consumption, either by respiratory electron transport inhibitors, or by
NO-mediated inhibition of O2 binding to cytochrome c oxidase, resulted in exacerbation of inflammation. Lentivirus-mediated
knockdown of hypoxia-inducible factor 1
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2255/1/STEM_CELLS_INTERNATIONAL____Article_Number_961307__;2015[96].pdf
Jash, Sukanta and Adhya, Samit (2015) Effects of Transient Hypoxia versus Prolonged Hypoxia on Satellite Cell Proliferation and Differentiation In Vivo. Stem Cells International (961307).
 
Relation http://dx.doi.org/10.1155/2015/961307
http://www.eprints.iicb.res.in/2255/