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To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases

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Title To be or not to be: The host genetic factor and beyond in
Helicobacter pylori mediated gastro-duodenal diseases
 
Creator Datta De, Dipanjana
Roychoudhury, Susanta
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description Helicobacter pylori (H. pylori ) have long been associated
with a spectrum of disease outcomes in the gastroduodenal
system. Heterogeneity in bacterial virulence
factors or strains is not enough to explain the divergent
disease phenotypes manifested by the infection.
This review focuses on host genetic factors that are
involved during infection and eventually are thought to
influence the disease phenotype. We have summarized the different host genes that have been investigated
for association studies in H. pylori mediated duodenal
ulcer or gastric cancer. We discuss that as the bacteria
co-evolved with the host; these host gene also show
much variation across different ethnic population.
We illustrate the allelic distribution of interleukin-1B,
across different population which is one of the most
popular candidate gene studied with respect to H.
pylori infections. Further, we highlight that several
polymorphisms in the pathway gene can by itself or
collectively affect the acid secretion pathway axis
(gastrin: somatostatin) thereby resulting in a spectrum
of disease phenotype
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2256/1/WORLD_JOURNAL_OF_GASTROENTEROLOGY__V_21_(_10_)_2883%2D2895;2015[43].pdf
Datta De, Dipanjana and Roychoudhury, Susanta (2015) To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases. World J Gastroenterol, 21 (10). pp. 2883-2895.
 
Relation http://dx.doi.org/10.3748/wjg.v21.i10.2883
http://www.eprints.iicb.res.in/2256/