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NAD(P)H Cytochrome b5 Oxidoreductase Deficiency in Leishmania major Results in Impaired Linoleate Synthesis Followed by Increased Oxidative Stress and Cell Death

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Title NAD(P)H Cytochrome b5 Oxidoreductase Deficiency in
Leishmania major Results in Impaired Linoleate Synthesis
Followed by Increased Oxidative Stress and Cell Death
 
Creator Mukherjee, Supratim
Sen Santara, Sumit
Das, Shantanabha
Bose, Moumita
Roy, Jayasree
Adak, Subrata
 
Subject Structural Biology & Bioinformatics
 
Description NAD(P)H cytochrome b5 oxidoreductase (Ncb5or) participates in a variety of metabolic conversions.
Results: A new Ncb5or acts as a redox partner of �12 fatty acid desaturase.
Conclusion: Ncb5or null mutant suffers from impaired linoleate synthesis leading to oxidative stress and cell death.
Significance: Our results have exposed a novel fatty acid synthesis pathway in L. major that differs from the mammalian
system.
 
Publisher American Society for Biochemistry and Molecular Biology
 
Date 1991
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2292/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY__V._287_(_42_)34992%2D35003.pdf
Mukherjee, Supratim and Sen Santara, Sumit and Das, Shantanabha and Bose, Moumita and Roy, Jayasree and Adak, Subrata (1991) NAD(P)H Cytochrome b5 Oxidoreductase Deficiency in Leishmania major Results in Impaired Linoleate Synthesis Followed by Increased Oxidative Stress and Cell Death. The Journal of Biological Chemistry, 287 (42). pp. 34992-35003.
 
Relation http://www.eprints.iicb.res.in/2292/