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Possible Existence of Dopaminergic Receptors on Cholinergic nerve Terminals in the Guinea pig Auerbach's Plexus

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Title Possible Existence of Dopaminergic Receptors on Cholinergic
nerve Terminals in the Guinea pig Auerbach's Plexus
 
Creator Das, M.
Chauhan, S.P.S
Ganguly, D.K
 
Subject Cell Biology & Physiology
 
Description In the Auerbach's plexus of guinea-pig ileum lower concentrations of oxotremorine(Oxo-T) produced an increase, whereas higher concentrations of Oxo-T caused inhibition of evoked acetylcholine (ACh) release, measured by bioassay using dorsal muscle of leech. Dopamine inhibited the increase in evoked release of ACh induced by Oxo-T as a function of its concentration and this inhibitory effect was nullified in presence of pimozide, the dopamine receptor antagonist. The results demonstrate existence of presynaptic dopamine receptors having inhibitory influence on excitatory presynaptic muscarinic receptors on regulation of ACh release. However, no physiological role of dopamine could be observed on ACh release in this preparation.
 
Publisher Elsevier
 
Date 1991
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2296/1/LIFE_SCIENCES__V._48___(_14)_1395%2D1399;1991.pdf
Das, M. and Chauhan, S.P.S and Ganguly, D.K (1991) Possible Existence of Dopaminergic Receptors on Cholinergic nerve Terminals in the Guinea pig Auerbach's Plexus. Life Sciences, 48 (14). pp. 1395-1399.
 
Relation http://www.eprints.iicb.res.in/2296/