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Studies on Proteins - Nucleic Acids Interactions in Regulation of Replication and Transcription

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Title Studies on Proteins - Nucleic Acids Interactions in
Regulation of Replication and Transcription
 
Creator Chakraborty, Prasenjit
Roy, Siddhartha
 
Subject Structural Biology & Bioinformatics
 
Description From our knowledge of living species, it is quite hard to imagine a living organism without
macromolecules even at its most primitive stage of evolution. Macromolecules found within
the cell such as proteins and nucleic acids are the essence of life. Synthesis of all
biomolecules found within a cell depends on the collaboration of several protein molecules.
Within the cell, proteins are used as enzyme for catalysis, structural components and energy
generation. Proteins are produced through an amazing assembly process, involving DNA as a
template for three types of RNA (mRNA, rRNA and tRNA), which in turn act as different
components of protein synthesis. The central dogma of molecular biology (Fig. I.1) deals
with this detailed residue-by-residue sequential transfer of information (1). It also states that
information can never be transferred from a protein to another protein or nucleic acid. Each
step in this complicated synthesis is carried out by an enzyme, which, being a protein had to
be synthesized by the same process. In other words, the end products of this reaction aid in
the synthesis of the starting components and catalyze each reaction along the way, making up
a complicated series of interrelationships. In order to understand life, the appearance of this
entire machinery must be explained.
 
Date 2014
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2329/1/Prosenjit.pdf
Chakraborty, Prasenjit and Roy, Siddhartha (2014) Studies on Proteins - Nucleic Acids Interactions in Regulation of Replication and Transcription. PhD thesis, University of Calcutta.
 
Relation http://www.eprints.iicb.res.in/2329/