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Eukaryotic tRNAs fingerprint invertebrates vis-àvis vertebrates

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Title Eukaryotic tRNAs fingerprint invertebrates vis-àvis
vertebrates
 
Creator Mitra, Sanga
Das, Pijush K
Samadder, Arpa
Das, Smarajit
Betai, Rupal
Chakrabarti, Jayprokas
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description During translation, aminoacyl-tRNA synthetases recognize the identities of the tRNAs to charge them with their respective amino acids. The conserved identities of 58,244 eukaryotic tRNAs of 24 invertebrates and 45 vertebrates in genomic tRNA database were analyzed and their novel features extracted. The internal promoter sequences, namely, A-Box and B-Box, were investigated and evidence gathered that the intervention of optional nucleotides at 17a and 17b correlated with the optimal length of the A-Box. The presence of canonical transcription terminator sequences at the immediate vicinity of tRNA genes was ventured. Even though non-canonical introns had been reported in red alga, green alga, and nucleomorph so far, fairly motivating evidence of their existence emerged in tRNA genes of other eukaryotes. Noncanonical introns were seen to interfere with the internal promoters in two cases, questioning their transcription fidelity. In a first of its kind, phylogenetic constructs based on tRNA molecules delineated and built the trees of the vast and diverse invertebrates and vertebrates. Finally, two tRNA models representing the invertebrates and the vertebrates were
drawn, by isolating the dominant consensus in the positional fluctuations of nucleotide compositions
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2339/1/Journal_of_Biomolecular_Structure_and_Dynamics%2CV._33%2C_(_10)_2104%E2%80%932120;_2015.pdf
Mitra, Sanga and Das, Pijush K and Samadder, Arpa and Das, Smarajit and Betai, Rupal and Chakrabarti, Jayprokas (2015) Eukaryotic tRNAs fingerprint invertebrates vis-àvis vertebrates. Journal of Biomolecular Structure and Dynamics, 33 (10). pp. 2104-2120.
 
Relation http://dx.doi.org/10.1080/07391102.2014.990925
http://www.eprints.iicb.res.in/2339/