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Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection

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Title Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection
 
Creator Biswas, Atanu
Kurkute, Prashant
Saleem, Suraiya
Jana, Batakrishna
Mohapatra, Saswat
Mondal, Prasenjit
Adak, Anindyasundar
Ghosh, Subhajit
Saha, Abhijit
Bhunia, Debmalya
Biswas, Subhash Chandra
Ghosh, Surajit
 
Subject Cell Biology & Physiology
Chemistry
 
Description Herein, we report a novel hexapeptide, derived from activity
dependent neuroprotective protein (ADNP),that spontaneously selfassembles to form antiparallel β-sheet structure and produces nanovesicles under physiological conditions. This peptide not only strongly binds with β-tubulin in the taxol binding site but also binds with the microtubule lattice in
vitro as well as in intracellular microtubule networks. Interestingly, it shows inhibition of amyloid fibril formation upon co-incubation with Aβ peptide following an interesting mechanistic pathway and excellent neuroprotection in PC12 cells treated with anti-nerve growth factor (NGF). The potential of this hexapeptide opens up a new paradigm in design and development of novel
therapeutics for AD.
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2381/1/ACS_CHEMICAL_NEUROSCIENCE__Vol.__6___(__8_)1309%2D1316;2015.pdf
Biswas, Atanu and Kurkute, Prashant and Saleem, Suraiya and Jana, Batakrishna and Mohapatra, Saswat and Mondal, Prasenjit and Adak, Anindyasundar and Ghosh, Subhajit and Saha, Abhijit and Bhunia, Debmalya and Biswas, Subhash Chandra and Ghosh, Surajit (2015) Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection. ACS Chemical Neuroscience, 6 (8). pp. 1309-1316.
 
Relation http://dx.doi.org/10.1021/acschemneuro.5b00149
http://www.eprints.iicb.res.in/2381/