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Plant glycosides in a liposomal drug-delivery system

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Title Plant glycosides in a liposomal drug-delivery system
 
Creator Das, Nirmalendu
Bachhawat, Bimal K
Mahato, Shashi B
Basu, Mukul K
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Plant glycosides were incorporated into the liposomal surface to study their sugar-specific uptake by various
tissues. Two steroid glycosides, namely floribundasaponin D, with rhamnose as terminal sugar, and gracillin, with glucose and rhamnose as end sugars, were selected for the purpose. '25I-human IgG encapsulated liposomes composed of egg lecithin (phosphatidylcholine), cholesterol, dicetyl phosphate (optional) and either floribundasaponin D or gracillin, when injected into the tail vein of rat, showed
significantly higher uptake in the rat liver than in appropriate controls. Whereas the uptake of
floribundasaponin D liposomes was observed to be non-specific, the increased uptake of the gracillin
liposomes, as judged from the inhibition studies with asppropriate sugars, was specific for glucose, although
the receptor was unable to distinguish between the a and /, anomers ('anomerically blind'). The liverperfusion
studies showed that the uptake of gracillin liposomes was mostly by non-parenchymal cells.
 
Publisher Portland Press
 
Date 1987
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2396/1/Biochem._J._(1987)_247%2C_359%2D361.pdf
Das, Nirmalendu and Bachhawat, Bimal K and Mahato, Shashi B and Basu, Mukul K (1987) Plant glycosides in a liposomal drug-delivery system. Biochemical Journal, 247. pp. 359-361. ISSN 0264-6021
 
Relation http://www.eprints.iicb.res.in/2396/