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Drug-resistant microorganisms with a higher fitness – can medicines boost pathogens?

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Title Drug-resistant microorganisms with a higher fitness – can
medicines boost pathogens?
 
Creator Vanaerschot, Manu
Decuypere, Saskia
Berg, Maya
Roy, Syamal
Dujardin, Jean-Claude
 
Subject Infectious Diseases and Immunology
 
Description Drug-resistant microorganisms (DRMs) are generally thought to suffer from a fitness cost associated with their drugresistant trait, inflicting them a disadvantage when the drug pressure reduces. However, Leishmania resistant to
pentavalent antimonies shows traits of a higher fitness compared to its sensitive counterparts. This is likely due the combination of an intracellular pathogen and a drug that targets the parasite’s general defense mechanisms while
at the same time stimulating the host’s immune system, resulting in a DRM that is better adapted to withstand the
host’s immune response. This review aims to highlight how this fitter DRM has emerged and how it might affect the
control of leishmaniasis. However, this unprecedented example of fitter antimony-resistant Leishmania donovani is
also of significance for the control of other microorganisms, warranting more caution when applying or designing drugs that attack their general defense mechanisms or interact with the host’s immune system.
 
Publisher Taylor & Francis
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2419/1/CRITICAL_REVIEWS_IN_MICROBIOLOGY__Volume__39____Issue__4____Pages__384%2D394.pdf
Vanaerschot, Manu and Decuypere, Saskia and Berg, Maya and Roy, Syamal and Dujardin, Jean-Claude (2013) Drug-resistant microorganisms with a higher fitness – can medicines boost pathogens? Critical Reviews in Microbiology, 39 (4). pp. 384-394. ISSN 1040-841X
 
Relation http://dx.doi.org/10.3109/1040841X.2012.716818
http://www.eprints.iicb.res.in/2419/