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Evaluation of the health effects, genetic damage and dna methylation induced by arsenic through drinking water

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Title Evaluation of the health effects, genetic damage and dna methylation induced by arsenic through drinking water
 
Creator Paul, Somnath
 
Subject Cell Biology & Physiology
Molecular & Human Genetics
 
Description Arsenic toxicity is a pandemic concern as addressed by the WHO to be one of the major natural calamities till date. More than 137 million individuals in nearly 70 nations are affected by arsenic mainly through drinking underground water. In the state of West Bengal, this scenario is
grim where nearly 26 million individuals in 9 out of 18 districts are affected by arsenic through drinking water. The arsenic content in these regions is nearly 10-20 times compared to the MPL of the WHO, i.e >10g/L. Although several preventive measures have been initiated by
installing arsenic filters in these regions, but still several regions are consuming arsenic lessened drinking water, that are still more than the WHO standard of 10g/L. Chronic exposure to arsenic leads to various types of patho-physiological end points like dermatological lesions, peripheral neuropathy, respiratory disorders and eye problems, etc in humans including several types of cancers.
Two epidemiological studies were conducted separately, to identify the ameliorative effect of reduction in arsenic through drinking water. In a two wave cross-sectional study, there were 189 arsenicosis patients and 171 unexposed individuals were recruited at two time points,
(2005–06 and 2010–11) with concomitant decrease in the level of arsenic exposure through drinking water for the arsenicosis group in 2010–11. Parameters evaluated in this study included dermatological, non-dermatological health status and cytogenetic damage. We identified that
reduction in arsenic through drinking water (190.1 g/l in 2005-06 to 37.94 g/l in 2010-11) had a positive effect on amelioration towards arsenic induced dermatological lesions (p
 
Date 2015
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2424/1/SOMNATH_PAUL_THESIS_for_CD.pdf
Paul, Somnath (2015) Evaluation of the health effects, genetic damage and dna methylation induced by arsenic through drinking water. PhD thesis, JU.
 
Relation http://www.eprints.iicb.res.in/2424/