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mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA (miRNA)-mediated Translation Repression in Mammalian Cells

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Title mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA
(miRNA)-mediated Translation Repression in Mammalian Cells
 
Creator Barman, Bahnisikha
Bhattacharyya, Suvendra Nath
 
Subject Molecular & Human Genetics
 
Description miRNA, Ago2, and target messages are enriched on ER in metazoan cells. Polysome association of newly formed mRNA
precedes Ago2 binding on ER membrane and its translation
repression. miRNA repression process is compartmentalized
in mammalian cells, and polysome association of
mRNA happens before the repression. This work provides a detailed understanding of the miRNA-mediated gene repression and mRNA compartmentalization in mammalian cells.
 
Publisher American Society for Biochemistry and Molecular Biology
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2456/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY__Volume__290___(_41_)___24650%2D24656;2015.pdf
Barman, Bahnisikha and Bhattacharyya, Suvendra Nath (2015) mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA (miRNA)-mediated Translation Repression in Mammalian Cells. The Journal of Biological Chemistry, 290 (41). pp. 24650-24656.
 
Relation http://dx.doi.org/10.1074/jbc.C115.661868
http://www.eprints.iicb.res.in/2456/