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Tricarbonyl 99mTc(I) and Re(I)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection

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Title Tricarbonyl 99mTc(I) and Re(I)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection
 
Creator Nayak, Dipak Kumar
Baishya, Rinku
Natarajan, Ramalingam
Sen, Tuhinadri
Chatterjee Debnath, Mita
 
Subject Infectious Diseases and Immunology
 
Description Methyl, ethyl and phenyl nitrofuryl thiosemicarbazone ligands (1, 2 and 3 respectively) were radiolabeled
with freshly prepared aqueous solution of a fac[99mTc(CO)3(H2O)3]+ precursor. The radiochemical yield was around 98% as determined by thin layer chromatography and HPLC. The complexes exhibited substantial stability. The corresponding Re(I) complexes were prepared from a Re(CO)5Br precursor to understand the coordination behavior of the ligands against a tricarbonyl rhenium(I) precursor. The rhenium(I) complexes were characterized by means of IR, NMR and mass spectroscopic studies as well as by X-ray
crystallography, and correlated with the technetium complexes by means of HPLC studies. Electrochemical
reduction of monomeric Re(CO)3-complexes of nitrofuryl ethyl thiosemicarbazone was also studied using cyclic voltammetry. Biodistribution studies of 99mTc(CO)3-labeled thiosemicarbazones in rats intramuscularly infected with S. aureus exhibited substantial in vivo stability of the complex and moderate accumulation at the site of focal infection
 
Publisher Royal Society of Chemistry
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2519/1/dalton_trans_thiosemicabazone_(1).pdf
Nayak, Dipak Kumar and Baishya, Rinku and Natarajan, Ramalingam and Sen, Tuhinadri and Chatterjee Debnath, Mita (2015) Tricarbonyl 99mTc(I) and Re(I)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection. Dalton Transactions, 44. pp. 16136-16148.
 
Relation http://dx.doi.org/10.1039/c5dt02264a
http://www.eprints.iicb.res.in/2519/