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Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines

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Title Copper(II)-Mediated Intermolecular C(sp2)−H Amination of
Benzamides with Electron-Rich Anilines
 
Creator Singh, Bijaya Kumar
Polley, Arghya
Jana, Ranjan
 
Subject Chemistry
 
Description Despite significant progress, copper-catalyzed/
mediated C−H amination reactions with electron-rich anilines
remain an unsolved problem due to catalyst deactivation and
deleterious side reactions. Herein, we report a copper(II)-
mediated C(sp2)−H amination of benzamides with electronically neutral or electron-rich anilines. A dramatic influence of silver(I) and tetrabutylammonium bromide was observed on the reaction outcome. The present protocol also demonstrates the synthesis of a number of nonsteroidal anti-inflammatory
drugs.
 
Publisher American Chemical Society
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2532/1/The_Journal_of_Organic_Chemistry.pdf
Singh, Bijaya Kumar and Polley, Arghya and Jana, Ranjan (2016) Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines. The Journal of Organic Chemistry, 81. 4295-4303.
 
Relation http://dx.doi.org/10.1021/acs.joc.6b00659
http://www.eprints.iicb.res.in/2532/