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Studies on the Extracellular Matrix Remodeling in Endometriosis: Involvement of Matrix Metalloproteinases

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Title Studies on the Extracellular Matrix Remodeling in Endometriosis: Involvement of Matrix Metalloproteinases
 
Creator Paul, Sumit
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description Endometriosis is a global health problem for reproductive women. About 10-15% of reproductive women are reported to be afflicted by this disorder (Wheeler, 1989). It can cripple a patient and pose severe risk factors for infertility and ovarian cancer (Somigliana et al., 1999c; Modugno et al., 2004). Most studies in reproductive biology are aimed towards understanding ovarian cancer while research on endometriosis is at its infancy. Endometriosis was first reported in medical history in 1899, in a 39 year old woman (Badawy et al., 1996). However, only in the last 10 years this debilitating disorder was recognized as the most important threat to female infertility. Sampson (1925) tried to explain the efflux of endometrium at foreign sites in the peritoneum by proposing the theory of ‘retrograde menstruation’ (Sampson, 1927). However, even today managing endometriosis remains a challenge for gynecologists. With the development of primate and rodent models for endometriosis, researchers are beginning to understand its etiology. Endometriosis is a disease of menstruating animals, and primate studies are critical for understanding molecular mechanism behind disease progression. With rodents possessing no menstrual cycle but only estrus cycle is not a replacement for women with endometriosis.
Endometrium is a classic case of an exception –it being the only tissue in female adults to undergo physiological remodeling in a cycle that repeats itself in every 28 days. The importance of aberrant remodeling of endometrium in the pathophysiology of endometriosis gained momentum with increased attention to matrix metalloproteinase (MMP)s. MMPs were first described in the tail of amphibian’s tadpole (Brinckerhoff and Matrisian, 2002). Since then MMPs have been reported in numerous pathologies notably arthritis, cancer and gastric ulceration (Woessner, 1991; Radisky et al., 2005; Ganguly et al., 2006).
 
Date 2010
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2567/1/Sumit_Paul_Thesis2010.pdf
Paul, Sumit (2010) Studies on the Extracellular Matrix Remodeling in Endometriosis: Involvement of Matrix Metalloproteinases. PhD thesis, J U .
 
Relation http://www.eprints.iicb.res.in/2567/