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A Smart Molecule for Selective Sensing of Nitric Oxide: Conversion of NO to HSNO; Relevance of Biological HSNO Formation

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Title A Smart Molecule for Selective Sensing of Nitric Oxide: Conversion of NO to HSNO; Relevance of Biological HSNO Formation
 
Creator Islam, Abu Saleh Musha
Bhowmick, Rahul
Pal, Kaberi
Katarkar, Atul
Chaudhuri, Keya
Ali, Mahammad
 
Subject Molecular & Human Genetics
 
Description A smart molecule, QT490, containing thiosemicarbazide
moiety acts as a highly selective turn-on in vitro NO sensor through the unprecedented NO-induced transformation of thiosemicarbazide moiety to 1,3,4-oxadiazole heterocycle with the concomitant release of HSNO, thereby eliminating any interference from various endogenous biomolecules including dehydroascorbic acid, ascorbic acid, etc. The
kinetic studies of the reactions between QT490 and NO provide a mechanistic insight into formation of HSNO/RSNO from the reaction between H2S/RSH and NO in the biological system. This novel probe is non-cytotoxic, cell permeable, water-soluble, and appropriate for intracellular cytoplasmic NO sensing with the possibilities of in vivo
applications.
 
Publisher American Chemical Society
 
Date 2017-03-27
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2664/1/Inorganic_Chemistry%2C_KC%2C_2017.pdf
Islam, Abu Saleh Musha and Bhowmick, Rahul and Pal, Kaberi and Katarkar, Atul and Chaudhuri, Keya and Ali, Mahammad (2017) A Smart Molecule for Selective Sensing of Nitric Oxide: Conversion of NO to HSNO; Relevance of Biological HSNO Formation. Inorganic Chemistry, 56. pp. 4324-4331. ISSN 2017, 56, 4324−4331
 
Relation http://dx.doi.org/10.1021/acs.inorgchem.6b02787
http://www.eprints.iicb.res.in/2664/